Plexxikon announced today the results of a Phase 1 extension study in metastatic colorectal cancer that showed clinical activity of PLX4032 as a single agent in this hard-to-treat patient population. PLX4032 (RG7204) is a novel, oral small molecule targeting an oncogenic BRAF mutation found in over 50 percent of melanomas, about 10 percent of colorectal cancers and eight percent of all solid tumors. PLX4032 is being co-developed by Roche and Plexxikon under their 2006 collaboration agreement. The data are being presented in a poster session (Abstract # 3534) at the 2010 Annual Meeting of the American Society for Clinical Oncology
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