Results 1 to 5 of 5
  1. #1
    Service Manager 5,000+ Posts


    BillyCarpenter's Avatar
    Join Date
    Aug 2020
    Location
    Long Beach, Mississippi
    Posts
    6,161
    Rep Power
    216

    Cancer’s ‘Achilles’ heel’ discovered by scientists

    Cancer’s ‘Achilles’ heel’ discovered by scientists




    ANCOUVER, British Columbia — Scientists may be one step closer to defeating cancer after finding what researchers at the University of British Columbia call the disease’s “Achilles’ heel.”


    Their study has uncovered a protein that fuels tumors when oxygen levels are low. It enables the cancerous growths to adapt and survive and become more aggressive.



    The enzyme, called CAIX (Carbonic Anhydrase IX), helps diseased cells spread to other organs. It could hold the key to new treatments for the deadliest forms of the disease, including breast, pancreatic, lungs, bowel, and prostate cancers.


    “Cancer cells depend on the CAIX enzyme to survive, which ultimately makes it their ‘Achilles heel.’ By inhibiting its activity, we can effectively stop the cells from growing,” says study senior author Professor Shoukat Dedhar in a university release.


    The findings, published in the journal Science Advances, will help researchers develop drugs that destroy solid tumors. These are the most common types that arise in the body. They rely on blood supply to deliver oxygen and nutrients which help tumors grow.


    As the tumors advance, the blood vessels are unable to provide enough oxygen to every part. Over time, the low-oxygen environment leads to a buildup of acid inside the cells. They overcome the stress by unleashing proteins, or enzymes, that neutralize the acidic conditions.


    Stopping cancer before it spreads
    This process is behind the spread, or metastasis, of cancer cells to other organs — which is what can kill patients. Finding a way to prevent cancer from metastasizing is the “Holy Grail” of cancer research. One of the enzymes which appears to do this is CAIX.


    The Canadian team previously identified a unique compound known as SLC-0111 as a powerful inhibitor. It is currently being tested in clinical trials. Experiments in mice with breast, pancreatic, and brain cancers revealed its effectiveness.

    The compound suppressed tumor growth and spread, although there were side-effects, with other cellular properties diminished. Now, the researchers have demonstrated other weaknesses in CAIX using a technique called genome-wide synthetic lethal screening. The powerful tool systematically deletes one gene at a time to determine if a cancer cell can be killed by eliminating the enzyme.


    Surprisingly, results pointed to an unexpected role of proteins and processes that control a form of cell death called ferroptosis. This process happens when iron builds up and weakens a tumor’s metabolism and cell membranes.


    “We now know that the CAIX enzyme blocks cancer cells from dying as a result of ferroptosis,” Dr. Dedhar adds. “Combining inhibitors of CAIX, including SLC-0111, with compounds known to bring about ferroptosis results in catastrophic cell death and debilitates tumor growth.”


    A large international effort is currently underway to identify drugs that induce ferroptosis. The study is a major step forward in this quest.
    Embrace the process, not the outcome.

  2. #2
    Retired 10,000+ Posts slimslob's Avatar
    Join Date
    May 2013
    Location
    Bakersfield, CA
    Posts
    15,858
    Rep Power
    446

    Re: Cancer’s ‘Achilles’ heel’ discovered by scientists


  3. #3
    Service Manager 10,000+ Posts


    Phil B.'s Avatar
    Join Date
    Jul 2016
    Location
    Raleigh NC
    Posts
    14,607
    Rep Power
    389

    Re: Cancer’s ‘Achilles’ heel’ discovered by scientists

    Quote Originally Posted by slimslob View Post
    Great report. Hopefully this will be the key for killing solid cancer tumors.

    Sent from my SM-G960U using Tapatalk

  4. #4
    IT Manager 10,000+ Posts bsm2's Avatar
    Join Date
    Feb 2008
    Location
    Don't be a Billy
    Posts
    11,197
    Rep Power
    150

    Re: Cancer’s ‘Achilles’ heel’ discovered by scientists

    Try Hydroxychloroquine what do you have to loose

  5. #5
    certified scrub 500+ Posts


    jmaister's Avatar
    Join Date
    Aug 2010
    Location
    somewhere i prefer not to share
    Posts
    736
    Rep Power
    36

    Re: Cancer’s ‘Achilles’ heel’ discovered by scientists

    Rip Norm

    Idling colour developers are not healthy developers.

Tags for this Thread

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Get the Android App
click or scan for the Copytechnet Mobile App

-= -= -= -= -=


IDrive Remote Backup

Lunarpages Internet Solutions

Advertise on Copytechnet

Your Link Here